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When developing a PowerPoint presentation, consider the following accessibility guidelines:

If you plan to distribute the PowerPoint as a .ppts or PDF file

Use templates to create slides in PowerPoint (use existing slide layouts or add slide layouts to the Slide Master)
Do not use text boxes to add content.
Avoid using the "Design Ideas" feature. Many of the layouts are not accessible.
All images should have appropriate, concise, alternative text. Include longer descriptions for more complex images. Do not use file names or rely on automatically generated descriptions for alt text.
Text in images should be accessible as plain text
Embed hyperlinks in text, do not paste an entire URL on a slide (unless it is extremely short).
Hyperlinks should use meaningful text. Do not use phrases such as "click here" or "read more", etc.
Slide titles should be unique. Avoid giving multiple slides the same title.
Whenever possible, create tables within PowerPoint. Do not copy and paste images of tables.
When saving files, use a meaningful file name. Check the document properties to ensure the correct language is selected.

Additional Tips

Use dark text on a light background
Font should be at least 22pt and preferably sans-serif
Use clear, concise language and avoid cluttering slides with too much content
Ensure all graphic elements have good contrast and clarity, not just slide text
Do not incorporate flashing elements and reduce or eliminate the use of animations
Moving elements (gifs, animations) should not start automatically when the slide is viewed
All embedded videos should be captioned

Use built-in accessibility checkers to do a preliminary check (this will catch some, but not all accessibility errors).
Check the reading order using the Reading Order tool.
Use the Outline view to see what content is visible to screen readers.

Speak clearly, at a regular pace, and encourage participants to do the same. Use a microphone if available
Read all text included on the slide when presenting, do not assume all participants can see what is being presented
When sharing your screen: share audio as well as video; avoid excessive scrolling; do not assume viewers will be able to read text on the screen; and, if using a cursor to indicate content, change the size and/or color to make it easier to see.